5/15/2023 0 Comments Side effect of amitiza![]() ![]() A population-based case–control study compared the outpatient cost of CIC patients over 2 years to be significantly higher than that of controls, when adjusted for comorbidities, age, and sex (US$6,284 vs US$5,254, respectively). 8 These patients may present repeatedly for evaluation of their constipation symptoms over prolonged periods of time. 6 Given the chronicity and suboptimal treatment of this ailment, the symptoms can often be debilitating and limiting. 6 Around 50% of patients reported that their quality of life (QOL) was affected by chronic constipation and expressed dissatisfaction with their current management. 7 The three most prevalent symptoms are straining, hard stool, and bloating. 6 In one study, 89% of patients reported little or no improvement in their condition over a 12- to 20-month period. 3, 5Ībout 70% of these patients have symptoms of constipation for >2 years. 4 The pooled prevalence of CIC is reported to be around 10%–15%. 3 Chronic idiopathic constipation (CIC) is defined as pain, difficulty, or lack of periodicity in defecation, without an identifiable organic cause. 1, 2 Constipation is more common in women and in populations from lower socioeconomic classes. Due to a lack of comparison with standard treatment modalities for severe constipation, its role in guideline-directed therapy is yet to be determined.Ĭonstipation is one of the most common ambulatory gastrointestinal (GI) conditions, with around 3.1–5.7 million outpatient clinic visits per year. ![]() Unfortunately, despite lubiprostone’s efficacy and great safety profile, it is currently underutilized in medical setting, with its high cost being the major limiting factor. ![]() Lubiprostone is regarded to be a safe drug for short-term use with minimal side effects however, its long-term safety profile is yet to be determined. Keywords: functional, gastrointestinal disorders, spontaneous bowel movements, secretory agents, abdominal pain, cost-effectiveness Corresponding improvements were also observed for abdominal bloating, discomfort, stool frequency, and straining symptoms among patients. In multiple randomized controlled trials, it has been found to have increased the number of spontaneous bowel movements at different time endpoints. In this review, we were able to conclude that lubiprostone, when used for chronic idiopathic constipation, has a significantly beneficial effect on both patients’ symptoms and their QOL. Pharmacologic options include fiber supplementation, laxatives, serotonergic agents, and prosecretory agents such as lubiprostone. Management strategies, focused on lifestyle changes, include increased exercise, a high-fiber diet, and toilet training. This may also result in frequent health care visits, increasing the burden of this ailment’s medical cost. Maham Hayat, 1 Hassaan Zia, 2 Salman Nusrat 2ġDepartment of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA 2Section of Digestive Diseases & Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USAĪbstract: Chronic idiopathic constipation, if inadequately treated, can be bothersome with a detrimental effect on patients’ quality of life (QOL). ![]()
0 Comments
Leave a Reply. |